Energy, Environmental Impact and Indoor Environmental Quality of Add-Ons in Buildings

On a European scale, the existing building stock has poor energy performance and partic-ularly vulnerable structures. Indeed, most of the existing buildings were built before the introduction of energy standards and under structural safety criteria different from those currently required. It is therefore necessary the intervention in existing buildings according to an integrated approach that contemplates both the structural safety and the energy efficiency of buildings. This study, con-sistently with the objectives of the European research project “Proactive synergy of integrated Efficient Technologies on buildings’ Envelopes (Pro-GET-OnE)”, proposes a retrofit intervention for a student dormitory of the National and Kapodistrian University of Athens. The scope of the evaluation is to understand how an integrated intervention, that implies a structural and energy retrofit, as well as a spatial redistribution, leads to an improvement of the Indoor Environmental Quality (IEQ). In detail, the structural retrofit was performed through exoskeleton that leads to the addition of new living spaces and to a remodeling of the building facades. The energy retrofit regarded all three levers of energy efficiency, and thus the building envelope, the microclimatic control systems, and the systems from renewable sources. The integrated intervention, in addition to a reduction of energy demand, has led to advantages in terms of IEQ. Thermal comfort, both during summer and winter, is improved and the hours of suitable CO2 concentration pass from 34% in the pre-retrofit stage up to 100% in the post retrofit stage

Spirulina in Clinical Practice: Evidence-Based Human Applications

Spirulina or Arthrospira is a blue-green alga that became famous after it was successfully used by NASA as a dietary supplement for astronauts on space missions. It has the ability to modulate immune functions and exhibits anti-inflammatory properties by inhibiting the release of histamine by mast cells. Multiple studies investigating the efficacy and the potential clinical applications of Spirulina in treating several diseases have been performed and a few randomized controlled trials and systematic reviews suggest that this alga may improve several symptoms and may even have an anticancer, antiviral and antiallergic effects. Current and potential clinical applications, issues of safety, indications, side-effects and levels of evidence are addressed in this review. Areas of ongoing and future research are also discussed

Embryo with XYY syndrome presenting with clubfoot: a case report

Talipes equinovarus (clubfoot) is a skeletal anomaly of the embryo’s legs, with a frequency of 1-3:1000 living born babies. It may occur as an independent anomaly, or as part of a syndrome with concomitant chromosomal abnormalities

Multi-disciplinary analysis of light shelves application within a student dormitory refurbishment

The achievement of sustainable cities and communities is closely linked to an accurate design of the buildings. In this context, the transparent elements of the building envelope have a crucial role since, on one hand, they are a bottleneck in regards to heat and mass transfers and sound propagation, while, on the other hand, they must allow daylight penetration. Thus, they are responsible for occupants' thermal and visual comfort and their health. Considering passive solutions for windows, the light shelves can improve natural light penetration, reducing the lights' electricity demand and controlling windows' related thermal aspects. The scientific literature is characterized by several studies that analyze this topic, which, however, focus only on the daylight field and sometimes the energy saving for lights. Moreover, they often refer to fixed sky type for the simulations. The aim of the present study is to analyze the application of the light shelves with a multi-disciplinary approach, by means of dynamic simulations, in the EnergyPlus engine, for a whole year. A new methodological approach is presented in order to investigate the technology under different fields of interest: daylight, lighting energy, cooling and heating needs, and thermo-hygrometric comfort. The case study chosen is an existing building, a student dormitory belonging to the University of Athens. It is subject to a deep energy renovation to conform to the "nearly Zero Energy Building" target, in the frame of a European research project called Pro-GET-onE (G.A No. 723747). By means of the calibrated numerical model of this HVAC-building system, ten different configurations of light shelves have been investigated. The best solution is given by the application of an internal horizontal light shelf placed at 50 cm from the top of the window with a depth of 90 or 60 cm. It has been found that despite the reduction in electricity demand for lighting, the variation in heating and cooling needs does not always lead to a benefit

Application of light shelves in a refurbished student dormitory: Energy, lightings and comfort aspects

The transparent elements of the building envelope have a crucial role not only in term of heat and mass transfers control, but also for natural light penetration, sound insulation, thermal and visual comfort of the occupants and their health. Among passive technologies, the light shelves could be architectural solutions for improving daylight penetration and for controlling thermal loads. The available research papers usually focus on one aspect. For this reason, the aim of the present study is to analyse the application of the light shelves with multidisciplinary approach and thus, taking into account: daylight, electricity for lighting, cooling and heating needs and thermo-hygrometric comfort. The case study is a real dormitory building placed in Athens and subject to a deep energy renovation toward the nearly zero energy building target. EnergyPlus, by means of DesignBuilder interface, has been used as dynamic simulation tool. Among ten different configurations, the optimal one turns out to be the internal horizontal light shelf placed at 50 cm from the top of the window with a depth of 90 cm or 60 cm. It has been found that in some cases the reduction of electricity for lighting cannot balance the variation in heating and cooling needs

Designing normative open virtual enterprises

This is an Accepted Manuscript of an article published by Taylor & Francis Group in Enterprise Information Systems on 23/03/2016, available online: http://www.tandfonline.com/10.1080/17517575.2015.1036927.[EN] There is an increasing interest on developing virtual enterprises in order to deal with the globalisation of the economy, the rapid growth of information technologies and the increase of competitiveness. In this paper we deal with the development of normative open virtual enterprises (NOVEs). They are systems with a global objective that are composed of a set of heterogeneous entities and enterprises that exchange services following a specific normative context. In order to analyse and design systems of this kind the multi-agent paradigm seems suitable because it offers a specific solution for supporting the social and contractual relationships between enterprises and for formalising their business processes. This paper presents how the Regulated Open Multiagent systems (ROMAS) methodology, an agent-oriented software methodology, can be used to analyse and design NOVEs. ROMAS offers a complete development process that allows identifying and formalising of the structure of NOVEs, their normative context and the interactions among their members. The use of ROMAS is exemplified by means of a case study that represents an automotive supply chain.This work was partially supported by the projects [PROMETEOII/2013/019], [TIN2012-36586-C03-01], [FP7-29493], [TIN2011-27652-C03-00] and [CSD2007-00022], and the CASES project within the 7th European Community Framework Programme [grant agreement number 294931].Garcia Marques, ME.; Giret Boggino, AS.; Botti Navarro, VJ. (2016). Designing normative open virtual enterprises. Enterprise Information Systems. 10(3):303-324. https://doi.org/10.1080/17517575.2015.1036927S303324103Cardoso, H. L., Urbano, J., Brandão, P., Rocha, A. P., & Oliveira, E. (2012). ANTE: Agreement Negotiation in Normative and Trust-Enabled Environments. Advances on Practical Applications of Agents and Multi-Agent Systems, 261-264. doi:10.1007/978-3-642-28786-2_33Chu, X. N., Tso, S. K., Zhang, W. J., & Li, Q. (2002). Partnership Synthesis for Virtual Enterprises. The International Journal of Advanced Manufacturing Technology, 19(5), 384-391. doi:10.1007/s001700200028Davidsson, P., & Jacobsson, A. (s. f.). Towards Norm-Governed Behavior in Virtual Enterprises. Studies in Computational Intelligence, 35-55. doi:10.1007/978-3-540-88071-4_3DeLoach, S. A., & Ojeda, J. C. G. (2010). O-MaSE: a customisable approach to designing and building complex, adaptive multi-agent systems. International Journal of Agent-Oriented Software Engineering, 4(3), 244. doi:10.1504/ijaose.2010.036984DI MARZO SERUGENDO, G., GLEIZES, M.-P., & KARAGEORGOS, A. (2005). Self-organization in multi-agent systems. The Knowledge Engineering Review, 20(2), 165-189. doi:10.1017/s0269888905000494Dignum, V. 2003. “A Model for Organizational Interaction: Based on Agents, Founded in Logic.” PhD diss., Utrecht University.Dignum, V., and F. Dignum. 2006.A Landscape of Agent Systems for the Real World. Technical Report 44-CS-2006-061. Utrecht: Institute of Information and Computing Sciences, Utrecht University.Dignum, V., Meyer, J.-J. C., Dignum, F., & Weigand, H. (2003). Formal Specification of Interaction in Agent Societies. Lecture Notes in Computer Science, 37-52. doi:10.1007/978-3-540-45133-4_4Garcia, E. 2013. “Engineering Regulated Open Multiagent Systems.” PhD diss., Universitat Politecnica de Valencia.Garcia, E., Giret, A., & Botti, V. (s. f.). Software Engineering for Service-Oriented MAS. Lecture Notes in Computer Science, 86-100. doi:10.1007/978-3-540-85834-8_9Garcia, E., Giret, A., & Botti, V. (2013). A Model-Driven CASE tool for developing and verifying regulated open MAS. Science of Computer Programming, 78(6), 695-704. doi:10.1016/j.scico.2011.10.009Garcia, E., Giret, A., & Botti, V. (2011). Evaluating software engineering techniques for developing complex systems with multiagent approaches. Information and Software Technology, 53(5), 494-506. doi:10.1016/j.infsof.2010.12.012Garcia, E., Giret, A., & Botti, V. (2011). Regulated Open Multi-Agent Systems Based on Contracts. Information Systems Development, 243-255. doi:10.1007/978-1-4419-9790-6_20Garcia, E., Giret, A., & Botti, V. (2014). ROMAS Methodology. Handbook on Agent-Oriented Design Processes, 331-369. doi:10.1007/978-3-642-39975-6_11Hollander, C. D., & Wu, A. S. (2011). The Current State of Normative Agent-Based Systems. Journal of Artificial Societies and Social Simulation, 14(2). doi:10.18564/jasss.1750HORLING, B., & LESSER, V. (2004). A survey of multi-agent organizational paradigms. The Knowledge Engineering Review, 19(4), 281-316. doi:10.1017/s0269888905000317Julian, V., Rebollo, M., Argente, E., Botti, V., Carrascosa, C., & Giret, A. (2009). Using THOMAS for Service Oriented Open MAS. Lecture Notes in Computer Science, 56-70. doi:10.1007/978-3-642-10739-9_5Luck, M., Barakat, L., Keppens, J., Mahmoud, S., Miles, S., Oren, N., … Taweel, A. (2011). Flexible Behaviour Regulation in Agent Based Systems. Lecture Notes in Computer Science, 99-113. doi:10.1007/978-3-642-22427-0_8Meneguzzi, F., Modgil, S., Oren, N., Miles, S., Luck, M., & Faci, N. (2012). Applying electronic contracting to the aerospace aftercare domain. Engineering Applications of Artificial Intelligence, 25(7), 1471-1487. doi:10.1016/j.engappai.2012.06.004Presley, A., Sarkis, J., Barnett, W., & Liles, D. (2001). International Journal of Flexible Manufacturing Systems, 13(2), 145-162. doi:10.1023/a:1011131417956Saeki, M., & Kaiya, H. (2008). Supporting the Elicitation of Requirements Compliant with Regulations. Active Flow and Combustion Control 2018, 228-242. doi:10.1007/978-3-540-69534-9_18Such, J. M., García-Fornes, A., Espinosa, A., & Bellver, J. (2013). Magentix2: A privacy-enhancing Agent Platform. Engineering Applications of Artificial Intelligence, 26(1), 96-109. doi:10.1016/j.engappai.2012.06.009Telang, P. R., & Singh, M. P. (2009). Enhancing Tropos with Commitments. Lecture Notes in Computer Science, 417-435. doi:10.1007/978-3-642-02463-4_22Wooldridgey, M., & Ciancarini, P. (2001). Agent-Oriented Software Engineering: The State of the Art. Lecture Notes in Computer Science, 1-28. doi:10.1007/3-540-44564-1_

Covid-19 disease, women’s predominant non-heparin vaccine-induced thrombotic thrombocytopenia and kounis syndrome: A passepartout cytokine storm interplay

Coronavirus disease 2019 (COVID-19) and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) constitute one of the deadliest pandemics in modern history demonstrating cardiovascular, gastrointestinal, hematologic, mucocutaneous, respiratory, neurological, renal and testicular manifestations and further complications. COVID-19-induced excessive immune response accompanied with uncontrolled release of cytokines culminating in cytokine storm seem to be the common pathogenetic mechanism of these complications. The aim of this narrative review is to elucidate the relation between anaphylaxis associated with profound hypotension or hypoxemia with pro-inflammatory cytokine release. COVID-19 relation with Kounis syndrome and post-COVID-19 vaccination correlation with heparin-induced thrombocytopenia with thrombosis (HITT), especially serious cerebral venous sinus thrombosis, were also reviewed. Methods: A current literature search in PubMed, Embase and Google databases was performed to reveal the pathophysiology, prevalence, clinical manifestation, correlation and treatment of COVID-19, anaphylaxis with profuse hypotension, Kounis acute coronary syndrome and thrombotic events post vaccination. Results: The same key immunological pathophysiology mechanisms and cells seem to underlie COVID-19 cardiovascular complications and the anaphylaxis-associated Kounis syndrome. The myocardial injury in patients with COVID-19 has been attributed to coronary spasm, plaque rupture and microthrombi formation, hypoxic injury or cytokine storm disposing the same pathophysiology with the three clinical variants of Kounis syndrome. COVID-19-interrelated vaccine excipients as polysorbate, polyethelene glycol (PEG) and trometamol constitute potential allergenic substances. Conclusion: Better acknowledgement of the pathophysiological mechanisms, clinical similarities, multiorgan complications of COVID-19 or other viral infections as dengue and human immunodeficiency viruses along with the action of inflammatory cells inducing the Kounis syndrome could identify better immunological approaches for prevention, treatment of the COVID-19 pandemic as well as post-COVID-19 vaccine adverse reactions

6li 28si reaction cross sections at sub barrier energies

Total reaction cross sections at near barrier energies (9-13 MeV) were measured for the system 6Li+28Si adopting a new technique. The results will be discussed in terms of the threshold anomaly at barrie

New measurement of neutron capture resonances of 209Bi

The neutron capture cross section of Bi209 has been measured at the CERN n TOF facility by employing the pulse-height-weighting technique. Improvements over previous measurements are mainly because of an optimized detection system, which led to a practically negligible neutron sensitivity. Additional experimental sources of systematic error, such as the electronic threshold in the detectors, summing of gamma-rays, internal electron conversion, and the isomeric state in bismuth, have been taken into account. Gamma-ray absorption effects inside the sample have been corrected by employing a nonpolynomial weighting function. Because Bi209 is the last stable isotope in the reaction path of the stellar s-process, the Maxwellian averaged capture cross section is important for the recycling of the reaction flow by alpha-decays. In the relevant stellar range of thermal energies between kT=5 and 8 keV our new capture rate is about 16% higher than the presently accepted value used for nucleosynthesis calculations. At this low temperature an important part of the heavy Pb-Bi isotopes are supposed to be synthesized by the s-process in the He shells of low mass, thermally pulsing asymptotic giant branch stars. With the improved set of cross sections we obtain an s-process fraction of 19(3)% of the solar bismuth abundance, resulting in an r-process residual of 81(3)%. The present (n,gamma) cross-section measurement is also of relevance for the design of accelerator driven systems based on a liquid metal Pb/Bi spallation target.Comment: 10 pages, 5figures, recently published in Phys. Rev.